For those who don't like stunt casting in animated movies, avert your eyes for a minute. Reese Witherspoon, Hugh Laurie, Seth Rogen, Stephen Colbert, Paul Rudd, Will Arnett, Kiefer Sutherland, Amy Poehler, Rainn Wilson, John Krasinski and Ed Helms are all featured here. Hugh Laurie as the maniacal Dr. Cockroach and Will Arnett as the strutting Missing Link are particularly good.
The main villain, Gallaxhar, might be a little intense for the young ones so keep that in mind. Also, Insectosaurus is pretty repulsive but that's usually a big plus for kids.
Dreamworks animated movies can be a little hit or miss - for every Shrek or Kung Fu Panda there's a Shark's Tale but I feel pretty comfortable putting this one down in the hit column.